While there is an increase in support for investors and businesses to find one another, little is known on how to efficiently and effectively conduct this activity. This guide directly addresses this knowledge gap and serves as a two-part handbook: First, as an introduction on the value effective ‘Matchmaking’ offers, suggesting a typology and ways in which providers of technical assistance (TA) can effectively engage in matchmaking. And secondly, as a practical guidebook, offering a theory of change and a practical step-by-step framework on how to structure matchmaking as part of programmatic activities. Overall, this guide encourages TA providers to broaden the application of matchmaking and to adopt a shift in perspective from conventional matchmaking activities.