Over the past decade, a new wave of pioneer healthcare initiatives has emerged that aims to improve the quality of care and access to healthcare of vulnerable populations in LMICs by building commercially viable and scalable enterprises. These pioneers are developing novel delivery models – inclusive clinics and hospitals, pharmacy-based, community-based, and risk-prevention models – and are innovating to solve patient pain points by making use of mobile and digital technologies, offering financing and insurance solutions, and improving access to preventative and primary care. This report reviews the preliminary findings of a study performed by the IQVIA Institute for Human Data Science, together with Hystra – a consultancy specialized in inclusive business solutions – to learn from pioneer organizations what underlies their early successes and what is limiting them from reaching further scale or impact. It reviews the landscape of global inclusive initiatives and identifies innovations that can strengthen the impact of businesses.